An Indo-American doctor and scientist has discovered a possible strategy to prevent life-threatening inflammation, lung damage and organ failure in patients diagnosed with COVID-19.
Posted online in the journal Cell, a researcher of Indian descent working at St. Jude Children’s Research Hospital in Tennessee, Dr. Thirumala-Devi Kannanagetti’s lab research identified the drugs, which revealed that the immune response of hyperflammonin associated with COVID 19 causes tissue damage and multi-organ failure in mice by triggering inflammatory cell death pathways.
The researchers detailed how the inflammatory cell death signaling pathway works, which could lead to potential treatments to disrupt the process.
Vice Chairman of the Department of Immunology at St. Jude Dr. “It is important to develop effective treatment strategies by understanding the pathways and mechanisms underlying this inflammation,” Kannezenti said.
Dr. Kannungani was born and raised in Telangana. He received his bachelor’s degree from Kakatiya University in Warangal, where he studied chemistry, zoology and botany. He then took M.Sc. and PhD from Osmania University in India. She joined St. Jude in Memphis, Tennessee, USA in 2007.
He added: “This survey provides that understanding. We have also identified specific cytokines that activate inflammatory cell death pathways and have great potential for the treatment of other highly fatal diseases, including COVID-19 and sepsis. ” said.
Other scholars were Shraddha Tuladhar, Parimal Sameer, Min Zheng, Balamurugan Sundaram, Balaji Banoth, RK Subbarao Malireddy, Patrick Schreiner, Geoffrey Neale, Peter Hogel, and Richard Weby of St. Jude; And Evan Peter Williams, Lillian Zalduondo, and Coleen Beth Jonson from the University of Tennessee Health Sciences Center.
COVID-19 is caused by the SARS-CoV-2 virus. The infection killed more than 1.2 million people in less than a year and sickened millions.
The infection is marked by an increase in the blood levels of several cytokines. These small proteins are mainly secreted by immune cells to ensure a rapid response to the virus. Certain cytokines also trigger inflammation.
The term cytokine storm has been used to describe dramatically elevated levels of cytokines in the blood and other immune changes seen in inflammatory disorders such as COVID-19, sepsis, and hemophagocytic lymphohydrocytosis (HLH), St. Jude’s The Release said.
But the specific pathways that elucidate cytokine storms and inflammation, lung damage, and consequent organ failures in COVID-19 and other disorders.
The cellular and molecular mechanisms that define cellular storms were also lacking. Dr. Kanengenti’s team focused on the selective set of elevated cytokines in COVID-19 patients. Scientists have shown that there is no cytokine-induced cell death in innate immune cells, he said.
“The results showed that inflammatory cell death induced COFID-19 through TNF-alpha and IFN-gamma,” said Dr Kannegantis.
“The results also suggest that therapies targeting this combination of cytokines are not only candidates for rapid clinical trials for the treatment of COVID-19, but many other deadly disorders associated with a cytokine storm,” he said. she declared.
“We were excited to connect these dots to understand how TNF-alpha and IFN-gamma trigger panoptosis,” said co-first author Rajendra Karki, scientist at Kanengetti’s lab.
“In fact, understanding how panoptosis contributes to disease and mortality is important to identifying treatments,” said Bhesh Raj Sharma, co-lead scientific author at the Kanergetti Lab.
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